CALCIUM SENNOSIDE

PRODUCT IDENTIFICATION
CAS NO. 81-27-6 (Sennoside A)
128-57-4 (Sennoside B)
517-43-1 (Sennoside A & B)
52730-37-7 (Calcium Salt)

CALCIUM SENNOSIDE
EINECS NO. 201-339-9 (Sennoside A)
204-895-0 (Sennoside B)
208-238-9(Sennoside A & B)
258-141-0 (Calcium Salt)
FORMULA C42H36CaO20
MOL WT. 900.81

H.S. CODE

 2938.90.0000

TOXICITY

 
SYNONYMS Sennoside A and B Calcium salts;
5,5'-Bis(beta-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'- bianthracene]-2,2'-dicarboxylic acid calcium salt; calcium (10S)-3-Carboxy-10-[2-carboxy-4-oxido-10-oxo- 5-[(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy- 9H-anthracen-9-yl]-9-oxo-8-[ (2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy- 10H-anthracen-1-olate
SMILES [Ca+2].c1c(cc(c2C(c3c(cccc3[C@@H](c12)[C@H]1c2cccc(c2C (c2c (cc(cc12)C(=O)[O-])O)=O)O[C@H]1[C@H](O)[C@@H](O)[C @H ](O)[C@H](O1)CO)O[C@H]1[C@H](O)[C@@H](O)[C@H](O) [C@ H](O1)CO)=O)O)C(=O)[O-]

CLASSIFICATION

Natural anthraquinone, Laxative

EXTRA NOTES

 Sennoside A refers to the R,R-isomer and B refers to the R,S-isomer.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE pale brownish hygroscopic powder
MELTING POINT  
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER Soluble
pH 6.3 - 7.3
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions. Hygroscopic.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Sennoside

PubChem Compound Summary - Calcium Sennoside

Drug Bank -  Sennoside

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Sennoside

http://www.ebi.ac.uk/ -  Sennoside

http://www.ncbi.nlm.nih.gov/ - Sennoside

Local
Cathartics promote or encourage defecation by accelerating the passage of feces through the large intestine, by influencing the consistency and amount of stool, and by facilitating the elimination of feces from the rectum. The terms laxative and cathartic reflect the typical intensity and latency of effect. A cathartic usually produces prompt fluid evacuation, while a laxative usually produces a soft formed stool over a protracted period. Cathartics or laxatives can be classified as belows:

  • Bulk-forming agents
    • Psyllium
    • Methylcellulose
    • Polycarbophils
  • Osmotics
    • Saline
    • Cleansing laxative
      • Polyethylene glycol
    • Hyperosmolar laxative
      • Lactulose
      • Sorbitol
      • Glycerin suppositories
  • Stimulants
    • Cascara
    • Sennosides
    • Phenolphthalein
    • Bisacodyl
    • Casanthranol
    • Aloe Vera
    • Castor Oil
  • Stool softener
    • Docusate Calcium
    • Docusate Sodium
    • Docusate Potassium
  • Lubricants/Emollients
    • Mineral oils

Sennoside: either hydroxyanthracene glycosides (designated A and B) derived from senna as the calcium salts; pale brownish hygroscopic powder; soluble in water and alcohol. They are used as a cathartic; administered orally. The chemical designation is 5,5'-bis(beta-D-gulcopyranosyloxy)-9,9',10,10'- tetrahydro-4,4'-dihydroxy-10,10'-dioxo [9,9'-bianthracene]-2,2'-dicarboxylic acid calciium salt.

Other sennosides

Sennoside E (or F) [CAS #: 11137-63-6]: (9,9'-Bianthracene)-2,2'-dicarboxylic acid, 5-((O- (carboxycarbonyl)- beta-D-glucopyranosyl)oxy)-5'-(beta-D- glucopyranosyloxy)-9,9',10,10'- tetrahydro-4,4'-dihydroxy- 10,10'-dioxo-, (R',R')-

Sennoside C (or D) [ CAS #: 37271-16-2; 26403-11-2; 28878-51-5]: (9,9'-Bianthracene)-2-carboxylic acid, 5,5'-bis(beta-D- glucopyranosyloxy)- 9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'- (hydroxymethyl)- 10,10'-dioxo-, (R',R')-

Sennoside G [CAS #: 66575-30-2; 73613-07-7]: (9,9'-Bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-D- glucopyranosyloxy) -9,9',10,10'-tetrahydro-4,4'- dihydroxy- 10,10'-dioxo-, (R',R')- 

 
SALES SPECIFICATION (STANDARD: BP, USP)

APPEARANCE

 pale brownish powder

IDENTIFICATION

Complies

SENNOSIDES

20% min or , 55 - 65% min or 90.0% min

pH

6.3 - 7.3

HEAVY METALS

10ppm max

WATER

5.% max

TOTAL MICROBIAL

5000 cfu/gr max

E COLI &SALMONELLA

none

MOULD & YEAST

100/gr max
TRANSPORTATION
PACKING

 
HAZARD CLASS  
UN NO. Not regulated
SAFETY INFORMATION
Hazard Symbols: XN, Risk Phrases: 40, Safety Phrases: 22-36

PRICE INFORMATION